Tachyphylaxis, Robert Wilson and HRT

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Photo by Anthony Tran on Unsplash

The British Menopause Society issued a newsletter this week warning women in the UK about high-dose estradiol prescriptions and the damage they can cause.

In some cases, the BMS points out, higher doses are appropriate because women are taking their hormones transdermally and don’t absorb well.

But in the UK, there is an approach I’ve covered before, one that involves prescribing ever-higher doses of estradiol, after starting out high in the first place. We are talking far in excess of product guidelines. Rogue levels.

And that can lead to tachyphylaxis, which is when people believe they need more of a drug to keep getting results. This happens with estrogen, as estrogen is addictive. And when it comes to menopause mood symptoms, the higher doses can be causing the symptoms that prompted the person taking them to seek help in the first place.

Everyone working in the field, and women experiencing these symptoms, as the BMS warns in their newsletter, nee…